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Objective:To explore influence of large dose γ globulin on myocardial cardiac myosin heavy chain (CM‐HC) own IgG antibody titer and therapeutic effect in patients with dilated cardiomyopathy (DCM) heart failure (HF) .Methods :A total of 160 DCM + HF patients hospitalized in our department of cardiology from Mar 2011 to May 2014 were selected .According to random number table ,they were randomly and equally divided into routine treatment group (n=80 ,RT group) and γglobulin group (n=80 ,received large dose γ globulin therapy based on RT group) .Cardiac function indexes ,IgG antibody titer and serum levels of cTnT and cTnI were observed and com‐pared between two groups before and after treatment .Results:Compared with before treatment after six -month treatment ,there were significant reductions in LVEDd [ (67.50 ± 5.50) mm vs .(56.50 ± 2.50) mm] and LVESd [ (55.50 ± 6.80) mm vs .(43.50 ± 2.30) mm] ,and significant rise in LVEF [ (33.50 ± 3.50)% vs .(53.50 ± 8.50)% ] in γglobulin group ,and only LVEF significantly rose [ (32.80 ± 4.20)% vs .(41.50 ± 5.50)% ] in RT group , P< 0.05 all;compared with RT group after six -month treatment , there were significant reductions in LVEDd [ (63.50 ± 2.50) mm vs .(56.50 ± 2.50) mm] and LVESd [ (51.60 ± 4.80) mm vs .(43.50 ± 2.30) mm] , and significant rise in LVEF in γglobulin group , P<0.05 all .On one ,three ,five and six months after treatment , IgG antibody titer significantly reduced in γglobulin group and they were significantly lower than those of RT group (P<0.05 all) .After six -month treatment ,cTnT and cTnI levels of both groups were significantly lower than those of before treatment ( P< 0.05 all ) , compared with RT group , there were significant reductions in cTnT [ (0.55 ± 0.10)μg/L vs .(0.26 ± 0.02)μg/L] and cTnI levels [ (1.20 ± 0.40)μg/L vs .(0.60 ± 0.10)μg/L] in γglobulin group , P<0.05 both .Conclusion:Large dose γglobulin can significantly improve myocardial function ,re‐duce myocardial CMHC own IgG antibody level and serum concentrations of cTnT and cTnI in DCM + HF pa‐tients ,so it’ s worth extending .
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Objective: To study the correlation between serum resistin (SR) level and blood pressure in patients with type 2 diabetes mellitus (T2DM) complicated hypertension. Methods: A total of 124 patients with T2DM complicated hypertension (T2DM + hypertension group), 85 patients with pure T2DM (pure DM group) and 71 normal subjects (normal control group) were enrolled. According to blood pressure level, T2DM + hypertension group was further divided into stage 1 subgroup (n=34), stage 2 subgroup (n=43) and stage 3 subgroup (n=47). Peripheral venous blood was taken to measure levels of SR and other indexes in three groups. Logistic multi-factor regression analysis was used to analyze the risk factors affecting blood pressure level. Kendall’s tau-b correlation analysis was used to analyze the correlation among SR, fasting insulin, quantitative insulin sensitivity check index, homeostasis model-insulin resistance index and blood pressure level. Results: Compared with normal control group, there were significant rise in SR levels [(7.21±2.65) ng/ml vs. (19.87±3.67) ng/ml vs. (31.32±3.89) ng/ml] in pure DM group and T2DM + hypertension group, and that of T2DM + hypertension group was significantly higher than that of pure DM group, P<0.01 all. Logistic multi-factor regression analysis indicated that SR level was an independent risk factor influencing blood pressure level of patients (R2=0.087, P<0.05). Kendall’ s tau-b correlation analysis indicated that SR level was significantly positively correlated with blood pressure level of patients with hypertension (r=0.202, P=0.001); after other influencing factors were controlled, the significant positive correlation still existed between them (r=0.233, P=0.022). Conclusion: Serum resistin level rise is a risk factor of patients with type 2 diabetes mellitus complicated hypertension, and it is significantly positively correlated with their blood pressure level.
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AIM: To investigate the effect of autologous bone marrow mononuclear cells (BM-MNCs) local transplantation (BM-LT) on a rabbit model of hindlimb ischemia. METHODS: After unilateral femoral artery and its branches were surgically ligated and excised in rabbits (n=14) 1 hour or so, autologous BM-MNCs were injected into the ischemic skeletal muscles in 7 rabbits, and phosphate buffered saline for another 7 ones as control. Hemodynamics parameters were measured at day 0, day 7 and day 28, respectively. On day 28, the animals were sacrificed in groups for pathological analysis. RESULTS: Compared with control group, color Doppler flow image in BM-LT group was recovered significantly, and its' systolic peak velocity and end-diastolic velocity were also improved (P
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Percutaneous coronary intervention(PCI) can effectively restore reperfusion of ischemic myocardium in patients with coronary artery disease.But currently PCI treatment is just available for a small proportion of the patients with coronary artery disease,so there was an insufficiency of PCI in patients with coronary artery disease.From the perspective of ethics,the reasons for the phenomenon and some feasible strategies for the problem are also analyzed in this paper.